Author: Damerakonda Kumaraswamy, V. Mallareddy

DOI:

The Mannich reaction on 3-aryl-2-thioxo-2, 3-dihydroquinazolin-4(1H)-one, in neutral medium and in alkaline medium with different secondary amines yielded a single product in each case. The mannich bases obtained have been characterized as the corresponding 1-N-substituted aminomethyl-3-aryl-3, 4-dihydro-4-oxoquinazolin-2-thione (II) and 2-S-substituted amino methyl thio-3-aryl 4(3H) quinazolinone (III) on the basis of analytical spectral data. These N- and S-Substituted compounds have been screened for their Anti- bacterial, Anti -fungal, Anti- inflammatory and Analgesic activities.

Keywords: Quinazolinone, N-Mannich base, S-Mannich base, aqueous potassium carbonate, Secondary amines, Analgesic activity, Anti-inflammatory activity.