Novelnitrogen-containing moieties were prepared and analyzed by various techniques like NMR and mass spectrometry. The antimicrobial and anti-oxidant behaviors of novel moieties have been screened. The synthesized moieties are better antimicrobial activities. The moieties 1-5 are the greatest antioxidant reagents in the DPPH process. The IC50 standards are 0.13, 0.14, 0.11, 0.16, and 0.11 μg/Ml, respectively. Compound 3, 5 (IC50 = 0.11 μg/mL) was the most potent compound with –OCH3 and –CH3 groups as substituents showing good antioxidant activity even at very low concentrations. The particulars of synthetic methods, spectroscopic data, and biological results are recorded.