GREEN SYNTHESIS OF 1,4- DISUBSTITUTED 1,2,3- TRIAZOLE ACETAMIDE DERIVATIVES BY UTILIZING THE CLICK CHEMISTRY APPROACH
A library of 1,4-disubstituted 1,2,3-triazole acetamide derivatives has been designed and synthesized via a click chemistry approach by using thiazole acetamide azide and acetylene derivative of quinoxaline is described. All the final compounds obtained in an excellent yield (>90%) and were well characterized by analytical spectroscopic methods like 1H NMR, 13C NMR, and Mass spectroscopy. The work reported herewith demonstrates the importance of green chemical synthesis using alternative solvents (water & n-butanol) in experiments to reduce the environmental impact of chemical processes.
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