Author: Mohit Ananda , Chandan C. , Abhishek Ghosh , Hridhya Mohandas, Rudranil Karmakar , Belagala Nagesh , S. Jubie , Sanal Dev K. T. and Jeyaprakash M. R.

DOI: http://doi.org/10.31788/RJC.2023.1638335

Abacavir Sulfate is a nucleoside analog and reverse transcriptase inhibitor which is used in combination with Lamivudine and Zidovudine for the treatment of HIV and AIDS. Abacavir has higher toxicity levels and is least stable in heat. The specified temperature for the drug was proposed to be not more than 25°C. The present study focuses on the stability-related problem of the ABC. The new synthetic moiety will help to stabilize the drug, it can be used as a pro-drug formulation and can take the present scenario of the market which supplies any anti-retroviral drug. The aim of the current study is to synthesize a novel drug using Schiff base synthesis and perform its structural elucidation by different modes of Instrumental Analysis and perform in silico studies. From the above study, we can conclude that the novel moiety is safe to use as a drug and could be explored furthermore for its use.

Keywords: Abacavir Sulfate, Schiff Base, Anti-Retroviral, HIV, Nucleoside Analogue, AIDS, Pro-Drug.