An easy, accurate, and precise RP-UPLC was established and also validated for simultaneous quantitation of Bupivacaine and Meloxicam in the formulation as well as in pure form. An acceptable separation of Bupivacaine and Meloxicam was shown by the developed technique Bupivacaine and Meloxicam retention times were 1.359 min. and 3.687 min. correspondingly. From regression equations, LOQ and LOD were obtained and observed to be 0.2ppm and 0.6ppm - Bupivacaine, 0.06 and 0.0 I 8ppm - Meloxicam, respectively. Stability studies of the injectable dosage form under forced degradation conditions of acid, alkali, peroxide, thermal, hydrolysis, and ultraviolet rays showed that the technique was particular without interferences from any type of possible contaminations that might form over the shelf life. The newly established RP-UPLC technique was stability indicating, accurate, rapid, and sensitive, for active pharmaceutical ingredients and pharmaceutical dosage forms