Author: Vasant M. Dhumal, Kalimoddin I. Momin Vishwas G. Mane PravinR. Jagtap Sharad P. Panchgalle and Vijaykumar S. More

DOI: http://doi.org/10.31788/RJC.2026.1939525

In the present investigation, a set of chalcone derivatives was synthesized and examined specifically, (E)-1-(2,6- dichloro-3-fluorophenyl)-3-phenylprop-2-en-1-one and its structural analogues were synthesized throughanefficient Claisen-Schmidt condensation reaction. The prepared compounds were thoroughly analysed throughvarious analytical methods such as infrared, nuclear magnetic resonance, and HRMS analysis, complementedbyelemental analysis to validate their structures and assess their purity. The antibacterial and antifungal potentials of the synthesized chalcone derivatives were tested versus various bacteria, as well as selected fungal strains. Theoutcomes indicated differential levels of microbial inhibition, with certain compounds showing notable effectivenessin comparison to conventional antimicrobial drugs. SAR analysis indicated that the existence of electron-removinggroups, for instance, chloro and fluoro groups, significantly influenced the antimicrobial potency. These findingshighlight the potential of chalcone derivatives as potential leads for the creation of novel antimicrobial drugs, providing a viable remedy for the growing problem of microbial resistance.

Keywords: Chalcone Derivatives, Synthesis, Characterisation, Antimicrobial Activities, Fluorinated Chalcones, Claisen-Schmidt Condensation.