DESIGN, SYNTHESIS, CHARACTERIZATION AND ANTIMICROBIAL ACTIVITY OF METAL(II)-AZOCOMPLEXES
Azo dyes and their derivatives with respective metal complexes have emerged as promising drug candidates duetotheir broad-spectrum physiological properties. The presently used medicines in the market are facing challenges likeantimicrobial resistance; it would insist to innovate therapeutic remedies through different strategies like syntheticmetalation. Among them, metal (II)-azo derivatives, especially the Cu, Co, Ni and Zn complexes, by modifications, can rationalize their efficacy against microorganisms, making them promising lead molecules for treating variousinfectious agents by the chelation process. Chelation will increase lipophilicity and reduce polarity; due to this, themolecules will easily enter the microbial cell membrane and disrupt the microbial activity. The present studyhighlights the synthesis of novel azo-metal complexes, which were characterized based on their UV-VIS, FTIR, NMR, XRD, physical, and thermal properties. The synthesized compounds were allowed for antimicrobial screeningagainst various bacterial and fungal strains; the results showed that the compounds showed significant to moderateactivity, and they were considered for promising lead molecules for future research work
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