Author: M. Sari, A. Rosyidah, I. M. Artika, A. Rasyid, D. A. Wulandari, M. Padri, F. Rachman, I. Hadiani and F. Untari

DOI: http://doi.org/10.31788/RJC.2026.1939692

The essential nature of green synthesis for gold nanoparticles (AuNPs) stems from their distinct physicochemical properties, which enable their use in various applications. This research presents an environmentally consciousmethod for synthesizing AuNPs using an aqueous extract from the brown alga, Turbinaria decurrens, collectedfromAmbon Bay waters, Indonesia. The study pursued two main goals: to develop a sustainable production route andtoassess the antibacterial and anticancer effectiveness of the resulting nanoparticles. The synthesis involved reducingchloroauric acid with the algal extract. The synthesis of AuNPs was verified using UV-vis spectroscopy, whichidentified a distinct Surface Plasmon Resonance (SPR) peak at 549 nm. Furthermore, FTIR analysis demonstratedthat the organic compounds present in the T. decurrens extract served a dual purpose, functioning as both stabilizingand capping agents for the nanoparticles. Temperature, incubation period, and precursor-to-extract ratio determinedthe formation rate, size, and morphology of the synthesized AuNPs. Bioactivity analysis demonstrated that AuNPsexhibited antibacterial capacity against various strains of human pathogens and anticancer activity, inhibiting breast cancer cells. These findings confirm the versatile abilities of AuNPs synthesized from an aqueous extract of T. decurrens, providing a promising treatment for infectious and cancer diseases. This study provides a cost-effective, scalable, and environmentally friendly nanoparticle synthesis platform based on marine resources. Furthermore, thiswork aligns with SDG-3: Good Health and Well-Being by advancing safer therapeutic strategies and SDG-12: Responsible Consumption and Production through green synthesis particles.

Keywords: Antibacterial Agent, Anticancer Agent, Gold Nanoparticles, Green Synthesis, Turbinaria decurrens