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AN IMPROVED SYNTHESIS OF C2 SYMMETRIC CHIRAL BIPYRIDINE-PINENE LIGANDS


Author: Nirupma Singh, V. Neeraja and N. Kundana
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Abstract

This communication depicts a short and improved synthesis of Pinene-based C2-symmetric chiral bipyridine ligands. These ligands are very suitable catalysts for high enantioselectivity towards various asymmetric reactions. Synthesisof the chiral ligand (15) was achieved in only five steps with improved yield as compared to the earlier synthesis, which involves a total of eleven steps with lower yield. The novel synthetic route will endorse the large-scalesynthesis of the ligand and, in turn, will help explore more asymmetric reactions in modern synthetic andpharmaceutical chemistry.

Keywords: Synthesis, Pinene, Bipyridine, Chiral, Ligand, Catalyst, Enantioselective






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