Author: N. S. Kadu, A. V. Ingle, S. Y. Pathan, A. A. Shaikh and P. D. Netankar

DOI: http://doi.org/10.31788/RJC.2026.1939748

In this study, the synthesis, characterisation, and biological evaluation of a series of novel N-(4-(4-(benzyloxy)-3- nitrophenyl)thiazol-2-yl)-1-(3-aryl-1-phenyl-1H-pyrazol-4-yl)methanimine derivatives have been carried out using4-(4-(benzyloxy)-3-nitrophenyl)thiazole-2-amine and substituted pyrazole aldehyde. These derivatives weresynthesised using a two-step process employing PEG-400 as a green solvent and citric acid as a catalyst. Synthesised compounds were confirmed using 1H-NMR and mass spectra. The method is efficient and eco-friendlywith high yield, and the synthesised compounds possess moderate to high antimicrobial activity.

Keywords: Pyrazole Aldehyde, Thiazole, Antimicrobial Activity, PEG-400, Schiff Bases.