Due to the bioactivity and the excellent properties of the rare earth elements, the effects of adding different amounts of La and Ce to the familiar base glass materials were studied. Different samples with and without rare earth elements were tested without farther calcinations. X-ray diffraction and IR spectrum were used to characterize the produced mixture where scanning and EDAX were used to study the change in the morphology by adding the rare earth elements or the immersion of the produced samples in simulated body fluid (SBF) liquid. The characterization of the samples specified the formation of some phases such as CaCe(PO₄)₂ and Ca₃La(PO₄)₃. Also, it is found that the produced powder have a nano-particle size ranging from 5 to 50 nm. On other hand, it is found that the base glass materials include rare earth elements (La and Ce) have an bioactive effects on the bacteria and the fungi